Estrogen receptors genotypes and canine mammary neoplasia
نویسندگان
چکیده
منابع مشابه
Estrogen Receptors in Canine Mammary Tumors1
The presence of estrogen receptor in 67 canine mammary lesions was correlated with pathological features of the dis ease. All tissue specimens were analyzed for estrogen receptor content by a sucrose gradient ultracentrifugation method pre viously used in analyzing human breast cancer cytosols. Patho logical features of the tissues were assessed by a veterinary pathologist without knowledge of ...
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BACKGROUND Mammary tumors represent the most common neoplastic disease in female dogs. Recently, the promoting role of prolactin (PRL) in the development of human breast carcinoma has been shown. Possible proliferative, anti-apoptotic, migratory and angiogenic effects of PRL on human mammary cancer cells in vitro and in vivo were suggested. The effects of PRL are mediated by its receptor, and a...
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The aims of this study were to investigate the serum and tissue content of androgens and estrogens in canine inflammatory mammary carcinomas (IMC) as well as in non-inflammatory malignant mammary tumors (MMT), and assessed the immunoexpression of estrogen and androgen receptors using immunohistochemistry. Profiles for the androgens dehydroepiandrosterone (DHEA), androstenedione (A4), and testos...
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Mammary gland tumors are by far the most commonly found tumors in domestic dogs. Effective therapeutic procedures with prompt accurate diagnoses are of prime importance for this life threatening neoplasm. Although immunohistochemical methods provide valuable information such as the location and semi-quantitative data of the interested antigens in particular tumors, conventional methods like his...
متن کاملClassification and grading of canine malignant mammary tumors
Histological grading is a good parameter to stratify tumors according to their biological aggressiveness. The Elston and Ellis grading method in humans, invasive ductal breast carcinomas and other invasive tumors are routinely used. The aims of this study were classification of mammary gland tumors and also application of a human grading method in canine mammary carcinoma. The samples included ...
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ژورنال
عنوان ژورنال: BMC Veterinary Research
سال: 2019
ISSN: 1746-6148
DOI: 10.1186/s12917-019-2062-y